The basic structure and composition of rabies virus is depicted in the longitudinal diagram below. The M protein is associated both with the envelope and the RNP and may be the central protein of rhabdovirus assembly. The glycoprotein forms approximately 400 trimeric spikes which are tightly arranged on the surface of the virus. Two other viral proteins, the phospoprotein and the large protein (L-protein or polymerase) are associated with the RNP. In the RNP, genomic RNA is tightly encased by the nucleoprotein. All rhabdoviruses have two major structural components: a helical ribonucleoprotein core (RNP) and a surrounding envelope. The rabies genome encodes five proteins: nucleoprotein (N), phosphoprotein (P), matrix protein (M), glycoprotein (G) and polymerase (L). Rhabdoviruses are approximately 180 nm long and 75 nm wide. The genus Lyssavirus includes rabies virus, Lagos bat, Mokola virus, Duvenhage virus, European bat virus 1 & 2 and Australian bat virus.
Within this group, viruses with a distinct “bullet” shape are classified in the Rhabdoviridae family, which includes at least three genera of animal viruses, Lyssavirus, Ephemerovirus, and Vesiculovirus. Rabies virus belongs to the order Mononegavirales, viruses with a nonsegmented, negative-stranded RNA genomes. The vast majority of rabies cases reported to the Centers for Disease Control and Prevention (CDC) each year occur in wild animals like bats, raccoons, skunks, and foxes, although any mammal can get rabies. The rabies virus infects the central nervous system of mammals, ultimately causing disease in the brain and death. Rabies is a preventable viral disease most often transmitted through the bite of a rabid animal.
0 kommentar(er)
